Making sense of genomics: targeting protein drivers of therapeutic resistance in colorectal cancer
Aim/goals:
- Complete the genomic profiling of our samples (580 mCRCs biopsies from 202 patients, including primary tumors, metastases before and at different times after TT).
- Profile mCRCs for proteomic and phosphoproteomic alterations to identify new actionable knots in relevant signaling protein pathways
- Develop an in vitro three-dimensional (3D) Patient Derived Organoids (PDO) assay to explore the determinants of targeted therapeutic failure.
Summary:
Key Researchers
-
Alan
Responsable de projet
Spatz -
Gerald
Responsable institutionnel
Batist -
Christoph
Responsable de projet
Borchers -
Mounib
Responsable de projet
Elchebly -
Andreas
Responsable de projet
Papadakis