A collaborative framework to perform ‘cancer therapy response integrative profiling’ (cTRIP) for melanoma patients treated with immune and targeted therapy
Project goals:
The overall goal of this project is to:
- Discover and validate predictive biomarkers and signatures linked to immune therapy response and clinical outcomes for melanoma patients with our cancer therapy response integrative profiling’ (cTRIP) platform;
- Elucidate the mechanistic relationship between biological, tumoral and immunological modulation impacting treatment efficacy;
- Identify biological, tumoral and immunological features involved in immunotherapy-related adverse events (irAEs);
- Evaluate the effects of targeted therapies on the tumor-intrinsic and peripheral immune landscape of melanoma
Summary:
Major strides in the treatment of advanced melanoma were achieved with the approval of therapies targeting the MAPK pathway and immune checkpoints inhibitors (ICI), which are now standard of care for melanoma. While these treatments have shown impressive clinical efficacy with durable responses, more than half of advanced melanoma patients do not respond. We still lack a clear understanding of the tumor-intrinsic and systemic features associated with response to ICIs. There has been no direct comparison of the efficacy of proposed biomarkers for ICI from a multi-platform molecular characterization analysis of melanomas, circulating tumor and immune cells and the microbiome from a single cohort.
This project was started in 2018 as part of the TFRI MoHCCN Montreal Cancer Consortium (MCC) Pilot Project. The MCC allowed for the establishment and support of three melanoma biobanks, the “Banque de tissus, de sang et de données cliniques associées à des fins de recherche sur les mélanomes et autres cancers de la peau”, at the CHUM, the “Skin Lesion BioBank” at the MUHC and the Montreal Immune-Related Adverse Event biobank at the JGH. These three biobanks have already recruited more than 500 patients treated with ICI and targeted agents as standard of care or on clinical trials, with extensive longitudinal tissue and blood collection, obtention of archival FFPE tissue, stool and derived cell-lines, as well as complete clinical annotation.
This study will be instrumental for any MoHCCN initiatives focusing on immune therapy, providing real world evidence for immune therapy-treated patients.
Key Researchers
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Ian
Responsable institutionnelComité de pilotagePrésident(e) de groupe de travailMembre de groupe de travail
Watson -
John
ChercheurMembre de groupe de travail
Stagg -
Rahima
Responsable de projet
Jamal -
Réjean
ChercheurMembre de groupe de travail
Lapointe -
Francis
Responsable de projet
Rodier -
Bertrand
Responsable de projetResponsable institutionnel
Routy -
Simon
Comité de pilotageResponsable de projetMembre de groupe de travail
Turcotte -
Joël
Chercheur
Claveau -
Émilie
Chercheur
Perron -
Christoph
Responsable de projet
Borchers -
Sonia
Responsable de projet
del Rincon -
April
Chercheur
Rose -
Wilson
Responsable de projet
Miller -
Alan
Responsable de projet
Spatz -
Peter
Responsable de projet
Siegel -
Lambert
Chercheur
Busque -
Guillaume
Responsable institutionnelMembre de groupe de travail
Bourque -
Hamed
Chercheur
Najafabadi -
Ioannis
Chercheur
Ragoussis -
May
Responsable de projet
Chergui -
Sinziana
Responsable de projet
Dumitra -
Marie-Christine
Responsable de projet
Guiot -
Ari
Responsable de projet
Meguerditchian -
Sarkis
Responsable de projet
Meterissian -
Catalin
Responsable de projet
Mihalcioiu -
Kevin
Responsable de projet
Petrecca -
Keith
Responsable de projet
Richardson -
Francine
Responsable de projet
Tremblay -
Beatrice
Responsable de projet
Wang -
Kevin
Responsable de projet
Watters -
Kerry
Chercheur
Savage